関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | Boron trifluoride etherate | HCID 8000 | — |
| 反応物 | 6-(1-Methoxy-3-methylnaphth-2-yl)-5-hexenoic acid | HCID 54260817 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 6-(3-Methyl-1,4-naphthoquinon-2-yl)-6-(4-methoxyphenyl)hexanoic acid | HCID 15230858 | — |
反応手順
To a solution of 6-(1-methoxy-3-methylnaphth-2-yl)-5-hexenoic acid (70 g) and phenol (70 g) in dichloromethane (500 ml) was added boron trifluoride etherate (95 g) and the reaction mixture was stirred for 3 days at 35° C. and poured into cooled water. The organic layer was washed with water, dried, and evaporated. The residue was purified with silica gel chromatography (eluent; toluene, 20% ethyl acetate/hexane, and ethyl acetate) to give the titled compound (30 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05804601 |
|---|
| 出典データセット | uspto-grants-1998_09 |
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| ORD ID | ord-1470db528db146f7b88e40d64e826c39 |
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| 出典メモ | uspto-grants-1998_09 |
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