Methanol → Methyl 3-(1,2-benzisoxazol-3-yl)propionate
反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][C:12]#N)=[N:2]1.CC[O:16][CH2:17]C.C[OH:20]>>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH2:10][CH2:11][C:12]([O:16][CH3:17])=[O:20])=[N:2]1参加物
4
実験手順
The nitrile was dissolved in methanol (200 ml) and HCI-saturated ether (200 ml) was added followed by stirring for 16 h at room temperature. The reaction mixture was concentrated in vacuo, water and ether added, and the phases separated. Drying of the ether phase over magnesium sulfate and removal of solvent in vacuo gave methyl 3-(1,2-benzisoxazol-3-yl)propionate (13 g) as an oil.
後処理
- concentrationThe reaction mixture was concentrated in vacuo, water and ether
- additionadded
- customthe phases separated
- dry with materialDrying of the ether phase over magnesium sulfate and removal of solvent in vacuo
出典と根拠
- ORDレコード
- ord-1fe95c5ef52b4167b23aeae7c40ee946
- 出典データセット
- uspto-grants-1998_09
- 特許番号
- US05807871
反応ノート
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