Sodium Methoxide → 5-(Methoxymethyl)quinolin-8-ol

HRID 23937

反応式

HRID 23937 の反応式
Cl.Cl[CH2:3][C:4]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2.[CH3:15][O-:16].[Na+]>CO>[CH3:15][O:16][CH2:3][C:4]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]2[C:5]=1[CH:6]=[CH:7][CH:8]=[N:9]2

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 122695968-Quinolinol, 5-(chloromethyl)-, hydrochloride (1:1)

生成物 1

HCID 6901295-(Methoxymethyl)quinolin-8-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-Chloromethyl-8-hydroxyquinoline hydrochloride (2.145 g; 9.3 mmol) was added to a mixture of sodium methoxide (1.763 g; 32.6 mmol) in MeOH (40 ml). The reaction mixture was stirred for about 4 h at room temperature, and then evaporated to dryness. The residue was dissolved in CHCl3 (100 ml, the solution was washed with water until a neutral pH was obtained, and was then washed with brine, dried over Na2SO4 and evaporated to dryness. The residue was extracted with hexane (100 ml). The hexane solution was evaporated to give the title product, 0.36 g (20%). M.p. 75-760° C. TLC (CHCl3/MeOH/NH3.9.5:0.5:0.1). Rf=0.36.

後処理

  1. customevaporated to dryness
  2. dissolutionThe residue was dissolved in CHCl3 (100 ml
  3. washthe solution was washed with water until a neutral pH
  4. customwas obtained
  5. washwas then washed with brine
  6. dry with materialdried over Na2SO4
  7. customevaporated to dryness
  8. extractionThe residue was extracted with hexane (100 ml)
  9. customThe hexane solution was evaporated

出典と根拠

ORDレコード
ord-2ec5d463dceb4791969bf473db271151
出典データセット
uspto-grants-2005_02
特許番号
US06855711B1

関連ノート

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