10-Methoxyiminostilbene → DE(5-carboxamide)oxcarbazepine
反応式
C[O:2][C:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[CH:4]=1>Cl>[O:2]=[C:3]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[CH2:4]1参加物
3
実験手順
22.3 g of 10-methoxy-5H-dibenz(b,f)azepine are heated under reflux with 100 ml of 2N hydrochloric acid for 2 hours. The gummy residue is extracted with chloroform (50÷50 ml), the combined extracts are washed with water and evaporated to dryness under vacuum. The residue is taken up into 200 ml of ethanol, treated with charcoal (2 g) for 1 h under reflux, filtered, evaporated to dryness under vacuum, finally taken up into 50÷50 ml of toluene, stripping thoroughly. The residue is kept for further working-up.
後処理
- extractionThe gummy residue is extracted with chloroform (50÷50 ml)
- washthe combined extracts are washed with water
- customevaporated to dryness under vacuum
- additiontreated with charcoal (2 g) for 1 h
- temperatureunder reflux
- filtrationfiltered
- customevaporated to dryness under vacuum
出典と根拠
- ORDレコード
- ord-9f518891f9d3470ca3e74e568cdebc92
- 出典データセット
- uspto-grants-1998_09
- 特許番号
- US05808058
反応ノート
読み込み中…