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Oxalyl chloride → 2-Chloro-4-methylpyrimidine-5-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 2-Chloro-4-methylpyrimidine-5-carboxylic acid | HCID 10487414 | — |
| 触媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Chlorine | HCID 24526 | — |
| 生成物 | 2-Chloro-4-methylpyrimidine-5-carbonyl chloride | HCID 21220650 | 61.3% |
反応手順
A solution of 2-chloro-4-methylpyrimidine-5-carboxylic acid (0.81 g, 4.70 mmol), oxalyl chloride (0.89 g, 7.05 mmol), DMF (2 drops) in CH2 Cl2 (23 mL) was stirred at room temperature under N2 for 4 h. The solution was concentrated and distilled to give the title compound (0.55 g, 61%); b.p. 90°-100° C., 1.3 mm/Hg; 1HNMR (CDCl3) δ d 9.02 (s, 1H), 2.74 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05811428 |
| 出典データセット | uspto-grants-1998_09 |
| ORD ID | ord-b5caa985263a478b8528cb22f5b22d33 |
| 出典メモ | uspto-grants-1998_09 |