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4-Nitrobenzenesulfonamide → N-(4-Nitrophenylsulphonyl)-4-[3-(2-benzyloxyphenyl),propyl]benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzenesulfonamide | HCID 22784 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 4-(3-(2-Benzyloxyphenyl)propyl]benzoic acid | HCID 18973764 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-(4-Nitrophenylsulphonyl)-4-[3-(2-benzyloxyphenyl),propyl]benzamide | HCID 18973867 | 68.6% |
反応手順
A mixture of 4-[3-(2-benzyloxyphenyl)propyl)benzoic acid 0.2 g), 4-nitrobenzenesulphonamide (0.12 g), DMAP (0.15 g) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (0.12 g) was stirred for 65 hours. The mixture was diluted with EtOAc, washed with water and brine, dried (MgSO4), filtered and evaporated. The residue was purified by flash chromatography on silica gel, eluting with ethyl acetate, to give the title compound (0.21 g) mpt. 112°-113° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05811459 |
| 出典データセット | uspto-grants-1998_09 |
| ORD ID | ord-88281c07bdd14ad4bf75ece76666dd74 |
| 出典メモ | uspto-grants-1998_09 |