Sulfuric Acid → 3-(Acetyloxy)-4-methylbenzoic acid

HRID 23953

反応式

HRID 23953 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[C:17](OC(=O)C)(=[O:19])[CH3:18]>O>[C:17]([O:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[CH3:11])[C:5]([OH:7])=[O:6])(=[O:19])[CH3:18]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 7918Acetic AnhydrideHCID 685123-Hydroxy-4-methylbenzoic acid

生成物 1

HCID 225699983-(Acetyloxy)-4-methylbenzoic acid収率 30%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

A solution of 3-hydroxy-4-methylbenzoic acid (3.0 g, 19.7 mmol) in acetic anhydride (5.6 mL) was treated with sulfuric acid (0.03 mL), heated to 70° C., cooled and diluted with water. The resulting solid was collected by filtration yielding 1.14 g (30%) of the title compound, which was used without further purification.

後処理

  1. temperaturecooled
  2. filtrationThe resulting solid was collected by filtration

出典と根拠

ORDレコード
ord-7908a31fbbb64d2282804f5d3fcaa166
出典データセット
uspto-grants-2005_02
特許番号
US06855715B1

関連ノート

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