4-Fluorophenol → Benzene, 1-(3-buten-1-yloxy)-4-fluoro-
反応式
Br[CH2:2][CH2:3][CH:4]=[CH2:5].[F:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:5][CH2:4][CH:3]=[CH2:2])=[CH:9][CH:8]=1参加物
5
実験手順
A solution of 4-bromo-1-butene (4.0 g), 4-fluorophenol (3.0 g), potassium carbonate (3.8 g) and acetone (75 ml) was heated at reflux over 16 hours. The mixture was then concentrated in vacuo, dluted with ether, washed with water followed by 1N sodium hydroxide, dried over sodium sulfate, filtered, and concentrated in vacuo. Chromatography on a silica gel column eluting with 25% ethyl acetate-hexane afforded 1.6 g of a colorless oil.
後処理
- temperatureat reflux over 16 hours
- concentrationThe mixture was then concentrated in vacuo
- washwashed with water
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
- washChromatography on a silica gel column eluting with 25% ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-8da0142d35ed43beaa759a5b59177616
- 出典データセット
- uspto-grants-1998_09
- 特許番号
- US05814651
反応ノート
読み込み中…