Acetic Acid → 9-methoxy-1-oxo-3,4-dihydro-2H-benzothiopheno[2,3-f][1,4]thiazepin-5-one
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:17][C:10]3[C:11](=[O:16])[NH:12][CH2:13][CH2:14][S:15][C:9]=3[C:7]=2[CH:8]=1.CC(O)=[O:20]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:17][C:10]3[C:11](=[O:16])[NH:12][CH2:13][CH2:14][S:15](=[O:20])[C:9]=3[C:7]=2[CH:8]=1参加物
3
実験手順
A mixture of 2,3-dihydro-9-methoxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(4H)-one (200 mg, 0.75 mmol) and NaBO3 -4H2O(116 mg, 0.75 mmol) in 18 mL of AcOH is stirred at room temperature overnight. The reaction mixture is filtered and 60 mL of water is added to the filtrate. Filtration provides 2,3-dihydro-9-methoxy-[1]benzothieno[2,3-f]-1,4-thiazepin-5(4H)-one-1-oxide in 69% yield; mp 215°-216° C. (dec).
後処理
- filtrationThe reaction mixture is filtered
- addition60 mL of water is added to the filtrate
- filtrationFiltration
出典と根拠
- ORDレコード
- ord-39bbe9d7670f4cb9931ca6c1c7a9a28a
- 出典データセット
- uspto-grants-1996_02
- 特許番号
- US05489586
反応ノート
読み込み中…