Methanol → Dimethyl 2,4-dichloroisophthaloate

HRID 2395556ノート

反応式

HRID 2395556 の反応式
[Cl:1][C:2]1[C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([Cl:15])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:16][OH:17]>>[Cl:1][C:2]1[C:10]([C:11]([O:13][CH3:14])=[O:12])=[C:9]([Cl:15])[CH:8]=[CH:7][C:3]=1[C:4]([O:17][CH3:16])=[O:5]

参加物

3

反応物 2

HCID 887MethanolHCID 189891562,4-Dichloro-3-methoxycarbonylbenzoylchloride

生成物 1

HCID 18989135Dimethyl 2,4-dichloroisophthaloate

実験手順

2,4-Dichloro-3-methoxycarbonylbenzoylchloride (34.76 g) was stirred and heated under reflux with methanol for 15 hours. After cooling, the solvent was evaporated and the residue recrystallised from cyclohexane to give dimethyl 2,4-dichloroisophthaloate (16.04 g) as a beige solid, NMR (DMSO D6) δ3.87 (3H,s), 3.94 (3H,s), 7.74 (1H,d), 7.94 (1H,d).

後処理

  1. temperatureheated
  2. temperatureAfter cooling
  3. customthe solvent was evaporated
  4. customthe residue recrystallised from cyclohexane

出典と根拠

ORDレコード
ord-50de8a8e5889458aa897d22b26e783fe
出典データセット
uspto-grants-1996_02
特許番号
US05489570

反応ノート

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