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Acetic Acid → 4-[(3,4-Dihydroxy-5-cyanophenyl)methylene]-3,5-pentanedione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Pentanal, 3-oxo- | HCID 12179 | — |
| 反応物 | 5-Formyl-2,3-dihydroxybenzonitrile | HCID 15292583 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-[(3,4-Dihydroxy-5-cyanophenyl)methylene]-3,5-pentanedione | HCID 54098226 | — |
反応手順
A mixture 1.6 g of 3,4-dihydroxy-5-cyanobenzaldehyde, 2.0 g of 3,5-pentanedione, 0.2 ml of piperidine and 0.6 ml of acetic acid in 70 ml of toluene was refluxed for 2 h with Dean-Stark separator. The solvent was evaporated in vacuo and the residue was crystallized from acetone-cyclohexane. mp 228°-232° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05489614 |
| 出典データセット | uspto-grants-1996_02 |
| ORD ID | ord-dd5989d39665475cb846a8388674bb9e |
| 出典メモ | uspto-grants-1996_02 |