Water → 4'-Hydroxy-3'-methoxy-5'-nitro-2-bromoisobutyrophenone
反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:13])[C:9]([Br:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[O:14][CH3:15].[N+:16]([O-])([OH:18])=[O:17].ClCCl.O>ClCCl>[OH:1][C:2]1[C:7]([N+:16]([O-:18])=[O:17])=[CH:6][C:5]([C:8](=[O:13])[C:9]([Br:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[O:14][CH3:15]参加物
5
実験手順
To a solution of 4'-hydroxy-3'-methoxy-2-bromoisobutyrophenone (10.0 g) in dichloromethane (80 ml) was gradually added 2M HNO3 -dichloromethane (19 ml). The mixture was stirred for 2 hours at 10° C. after which water (100 ml) was added. The organic phase was separated, dried over Na2SO4 and evaporated to dryness. Ether (20 ml) was added. The resulting crystals were filtered and washed with ether. Yield 3.3 g.
後処理
- additionwas added
- customThe organic phase was separated
- dry with materialdried over Na2SO4
- customevaporated to dryness
- additionEther (20 ml) was added
- filtrationThe resulting crystals were filtered
- washwashed with ether
出典と根拠
- ORDレコード
- ord-6ea78b2a36274249a1145ea3a842b98d
- 出典データセット
- uspto-grants-1996_02
- 特許番号
- US05489614
反応ノート
読み込み中…