Boron tribromide → 4-(Chloromethyl)-2,6-dimethylphenol

HRID 2395733ノート

反応式

HRID 2395733 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH3:12])[C:9]=1[O:10]C)[CH2:5][Cl:6].B(Br)(Br)Br.C(=O)(O)[O-].[Na+]>ClCCl>[CH3:12][C:8]1[CH:7]=[C:4]([CH:3]=[C:2]([CH3:1])[C:9]=1[OH:10])[CH2:5][Cl:6]

参加物

5

反応物 3

HCID 25134Boron tribromideHCID 516892Sodium BicarbonateHCID 194187985-(Chloromethyl)-2-methoxy-1,3-dimethylbenzene

生成物 1

HCID 2786614-(Chloromethyl)-2,6-dimethylphenol

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3,5-Dimethyl-4-methoxybenzyl chloride (I, PREPARATION 4, 1.8 g) is added to a solution of boron tribromide (1.5 m) in dichloromethane (70 ml) at 78°. The solution is allowed gradually to warm to 20°-25° overnight. The reaction is poured into an aqueous sodium bicarbonate solution, and the phases are separated. The dichloromethane phase is washed once with water and then with concentrated hydrochloric acid. The dried (sodium sulfate) organic phase is concentrated under reduced pressure to give the title compound.

後処理

  1. temperatureto warm to 20°-25° overnight
  2. customthe phases are separated
  3. washThe dichloromethane phase is washed once with water
  4. dry with materialThe dried (sodium sulfate) organic phase
  5. concentrationis concentrated under reduced pressure

出典と根拠

ORDレコード
ord-76804c5c7d504549808c4567025612b7
出典データセット
uspto-grants-1996_02
特許番号
US05489593

反応ノート

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