Potassium Hydroxide → 6-(dimethylamino)-1H-indole-2-carboxylic acid

HRID 2395773ノート

反応式

HRID 2395773 の反応式
[CH3:1][N:2]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[C:9]([C:13]([O:15]C)=[O:14])[NH:10]2)=[CH:6][CH:5]=1)[CH3:3].[OH-].[K+]>>[CH3:3][N:2]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[C:9]([C:13]([OH:15])=[O:14])[NH:10]2)=[CH:6][CH:5]=1)[CH3:1]

参加物

3

反応物 2

HCID 14797Potassium HydroxideHCID 4715276methyl 6-(dimethylamino)-1H-indole-2-carboxylate

生成物 1

HCID 51599086-(dimethylamino)-1H-indole-2-carboxylic acid

実験手順

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 6-(N,N-dimethylamino)indole-2-carboxylate (PREPARATION 88, 0.80 g), potassium hydroxide (0.25 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.62, 7.13, 7.11, 7.01, and 3.11 δ.

後処理

  1. customthe general procedure of PREPARATION 63

出典と根拠

ORDレコード
ord-2a2183cb021549fb8816cb1dc407b928
出典データセット
uspto-grants-1996_02
特許番号
US05489593

反応ノート

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