化工社化工社 化学情報印刷レポート · 研究参考用
Citric Acid → Sufentanil Citrate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Citric Acid | HCID 311 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Sufentanil | HCID 41693 | — |
| 反応物 | 164790-60-7 | HCID 18463211 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Sufentanil Citrate | HCID 65494 | — |
反応手順
Sufentanil HCl obtained in Example 8 was suspended in hot water and adjusted to pH 10-11 with 10% aqueous potassium hydroxide and extracted with ether. The organic layer washed with water, dried and evaporated to give the free base with an LC purity profile of 99.62%. An equivalent of sufentanil free base with anhydrous citric acid was warmed in 100% ethanol. After removal of ethanol the fluffy white powder was dried in the vacuum oven at 56° C. for 48 hrs. Sufentanil citrate thus obtained passed all USP tests.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05489689 |
| 出典データセット | uspto-grants-1996_02 |
| ORD ID | ord-c4d7fd8d38be478e8f997c76ebc4fde9 |
| 出典メモ | uspto-grants-1996_02 |