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Acetic Acid → 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 4-Vinylpyridine | HCID 7502 | — |
| 反応物 | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 1-Boc-4-[2-(4-pyridinyl)ethyl]piperazine | HCID 22321631 | 46.3% |
反応手順
1-Boc-piperazine (4.0 g, 21.5 mmol), 4-vinylpyridine (2.94 g, 27.9 mmol), and acetic acid (1.29 g, 21.5 mmol) were mixed in ethanol and heated to reflux for 48 h. The mixture was cooled to room temperature and concentrated under vacuum to provide 1-Boc-4-[2-(4-pyridinyl)ethyl]-piperazine (2.9 g, 45%) as an off white solid. The product was used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06855715B1 |
| 出典データセット | uspto-grants-2005_02 |
| ORD ID | ord-0cbde3c2a82a4113837f2babf03f86ec |
| 出典メモ | uspto-grants-2005_02 |