Ethyl 2-pyridylacetate → Nsc74475

HRID 23961

反応式

HRID 23961 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].[N:13]([O-])=[O:14].[Na+]>C(O)(=O)C.O>[OH:14][N:13]=[C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9]

参加物

5

反応物 2

HCID 75960Ethyl 2-pyridylacetateHCID 23668193Sodium Nitrite

生成物 1

HCID 135543845Nsc74475収率 95.2%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒2 回

実験手順

To a stirring solution of ethyl pyridine-2-acetate (12.6 g, 76.3 mmol) in acetic acid (19 mL) at 5° C. was added a solution of sodium nitrite (6.05 g, 87.7 mmol) in water (12 mL) at a rate sufficient to maintain the internal temperature below 15° C. After complete addition and an additional 30 min, an additional 30 mL of water was added. The resulting white precipitate was filtered, washed with water, saturated aqueous NaHCO3, and again with water. The solid was then dried under vacuum to give 14.1 g (95%) of the title compound.

後処理

  1. temperatureto maintain the internal temperature below 15° C
  2. additionAfter complete addition
  3. filtrationThe resulting white precipitate was filtered
  4. washwashed with water, saturated aqueous NaHCO3
  5. customThe solid was then dried under vacuum

出典と根拠

ORDレコード
ord-a7f6fb272a334a2483dacd0a71bbf705
出典データセット
uspto-grants-2005_02
特許番号
US06855715B1

関連ノート

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