Potassium Hydroxide → Imidazo(1,2-a)pyrimidine-2-carboxylic acid

HRID 23962ノート

反応式

HRID 23962 の反応式
[N:1]1[C:2]([C:10]([O-:12])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=12.[OH-].[K+]>C(O)C>[N:1]1[C:2]([C:10]([OH:12])=[O:11])=[CH:3][N:4]2[CH:9]=[CH:8][CH:7]=[N:6][C:5]=12

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 6987274Imidazo[1,2-a]pyrimidine-2-carboxylate

生成物 1

HCID 326100Imidazo(1,2-a)pyrimidine-2-carboxylic acid収率 83%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirring solution of ethyl 1-(imidazo[1,2-a]pyrimidine-2-carboxylate (1 g, 5.2 mmol) [Abignente, et al. Eur. J. Med. Chem. (1994) 29, 279] in ethanol (30 mL) was added 2 N aqueous KOH (10 mL, 20 mmol). The solution was heated to reflux; and after 2 h, the heating mantle was removed, the solution was allowed to cool and the solvent was removed by rotary evaporation. The residue was dissolved in water (20 mL) and acidified to pH 3 with 5 N HCl. The resulting precipitate was filtered, washed with water and dried in vacuo to give 700 mg (83%) of a tan solid.

後処理

  1. temperatureThe solution was heated to reflux
  2. customthe heating mantle was removed
  3. temperatureto cool
  4. customthe solvent was removed by rotary evaporation
  5. dissolutionThe residue was dissolved in water (20 mL)
  6. filtrationThe resulting precipitate was filtered
  7. washwashed with water
  8. customdried in vacuo

出典と根拠

ORDレコード
ord-81b55db0f6af485f8483d472d1550f6b
出典データセット
uspto-grants-2005_02
特許番号
US06855715B1

反応ノート

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