2-Amino-5-(trifluoromethyl)pyridine → 2-Chloroamino-5-trifluoromethylpyridine
反応式
NC1C=CC(C(F)(F)F)=CN=1.[Cl:12][NH:13][C:14]1[C:19](Cl)=[CH:18][C:17]([C:21]([F:24])([F:23])[F:22])=[CH:16][N:15]=1>>[Cl:12][NH:13][C:14]1[CH:19]=[CH:18][C:17]([C:21]([F:23])([F:22])[F:24])=[CH:16][N:15]=1参加物
3
反応条件
- 温度
- 20 °C
実験手順
Then, 16.2 g (0.1 mol) of 2-amino-5-trifluoromethylpyridine was added to the reaction product, and the mixture was heated to 20° C. and stirred at the same temperature for two hours. The reaction product was analyzed by liquid chromatography, whereby 2-chloroamino-3-chloro-5-trifluoromethylpyridine was found to have decreased to 1%, and 2-chloroamino-5-trifluoromethylpyridine was formed afresh in an amount of 31%, and 2-amino-3-chloro-5-trifluoromethylpyridine was formed in an amount of 30%. The rest was the hydrochloride of 2-amino-3-chloro-5-trimethylpyridine.
出典と根拠
- ORDレコード
- ord-904f24d3c6e744ce8b46d5609b8aac5f
- 出典データセット
- uspto-grants-1996_02
- 特許番号
- US05491239
反応ノート
読み込み中…