Hydrochloric Acid → (S)-2-amino-3-phenylpropan-1-ol hydrochloride

HRID 2396440

反応式

HRID 2396440 の反応式
C(OC([NH:8]C(C1C=CC=CC=1)(O)CC)=O)(C)(C)C.[ClH:19].[C:20]1([CH3:26])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[O:27]1CCO[CH2:29][CH2:28]1>>[ClH:19].[NH2:8][C@@H:29]([CH2:26][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[CH2:28][OH:27]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 312751,4-DioxaneHCID 77504178Tert-butoxycarbonylamino-1-phenyl-propan-1-ol

生成物 1

HCID 69017766(S)-2-amino-3-phenylpropan-1-ol hydrochloride

実験手順

A solution of 20.10 g (80.00 mmol) of (S)-2-(tert-butoxycarbonylamino-1-phenyl-propan-1-ol [J. Med. Chem. 33, 2707 (1990)] in 200 ml of a 4N solution of gaseous hydrogen chloride in anhydrous dioxane is stirred at room temperature for 30 minutes. Thereafter, 60 ml of toluene are added and the mixture is concentrated in vacuo. This operation is repeated twice more, and the residue is then titrated with a little ether, filtered off with suction and dried under a high vacuum over KOH. 14.14 g (94% of theory) of the title compound are obtained as colourless crystals.

後処理

  1. concentrationthe mixture is concentrated in vacuo
  2. filtrationfiltered off with suction
  3. dry with materialdried under a high vacuum over KOH

出典と根拠

ORDレコード
ord-8e8c2d677f86438e8cab5be150c9d721
出典データセット
uspto-grants-1996_02
特許番号
US05492896

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