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3-Bromo-1-propanol → 3-[(4,6-Diphenyl-2-pyridyl)oxy]-1-propanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromo-1-propanol | HCID 12308 | — |
| 反応物 | 4,6-Diphenyl-2-pyridone | HCID 3846201 | — |
| 触媒 | HCID 178418647 | HCID 178418647 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-[(4,6-Diphenyl-2-pyridyl)oxy]-1-propanol | HCID 18987283 | — |
反応手順
The procedure in Example 4 is followed but using 4,6-diphenyl-2-pyridone (15 g), freshly distilled 3-bromo-1-propanol (16.5 cc), silver carbonate (8.4 g) and toluene (600 cc). The reaction mixture is refluxed for 144 hours. The product is purified by chromatography under pressure on silica gel (30-60 mm; eluent: n-hexane-ethyl acetate 7-3). (white solid; m.p.=94° C.)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05492915 |
| 出典データセット | uspto-grants-1996_02 |
| ORD ID | ord-3ba0fce85e394da99a4bd7067d820af7 |
| 出典メモ | uspto-grants-1996_02 |