Hydrogen Peroxide → Pyridine, 3-(phenylmethyl)-, 1-oxide

HRID 2396758ノート

反応式

HRID 2396758 の反応式
[CH2:1]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:14]O>C(O)(=O)C>[CH2:1]([C:8]1[CH:9]=[N+:10]([O-:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 784Hydrogen Peroxide2 回HCID 121123-Benzylpyridine

生成物 1

HCID 54142008Pyridine, 3-(phenylmethyl)-, 1-oxide収率 100%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 3-benzylpyridine (25 g, 0.148 tool) in hydrogen peroxide (30%, 15.1 mL) and acetic acid (100 mL) was refluxed for one day. Then more hydrogen peroxide (3 mL) was added and the resulting mixture was refluxed overnight. The reaction mixture was then evaporated and partitioned between a mixture of 3 N HCl, brine and dichloromethane. The organic layer was separated, dried and evaporated to give the desired compound (27.6 g, 100%).

後処理

  1. temperaturethe resulting mixture was refluxed overnight
  2. customThe reaction mixture was then evaporated
  3. custompartitioned between a mixture of 3 N HCl, brine and dichloromethane
  4. customThe organic layer was separated
  5. customdried
  6. customevaporated

出典と根拠

ORDレコード
ord-3e12e8445c50462ea540c0fda3bb7416
出典データセット
uspto-grants-1996_02
特許番号
US05494919

反応ノート

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