Triethylamine → (+/-)-1-Acetyl-4-acetylthio-2-pyrrolidone

HRID 2396875

反応式

HRID 2396875 の反応式
[C:1]([N:4]1[CH2:8][C@H:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2].C(N(CC)CC)C.S1C=CC=C1CC(O)=O>C(OCC)(=O)C>[C:1]([N:4]1[CH2:8][CH:7]([C:9](=[O:11])[CH3:10])[CH2:6][C:5]1=[S:12])(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 159702-Thiopheneacetic acidHCID 86748734(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone

生成物 1

HCID 86748735(+/-)-1-Acetyl-4-acetylthio-2-pyrrolidone収率 90%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

(+)-(4R)-1-Acetyl-4-acetylthio-2-pyrrolidone (3 g) and triethylamine (2.1 ml) are dissolved in ethyl acetate (30 ml), and the mixture is refluxed for three hours, and then allowed to stand at room temperature for 8 hours. To the reaction solution is added thiolacetic acid (1.2 ml), and the mixture is stirred at room temperature for 5 hours. The reaction solution is washed with water, dried, and evaporated to remove the solvent to give (±)-1-acetyl-4-acetylthio-2-pyrrolidone (2.7 g).

後処理

  1. temperaturethe mixture is refluxed for three hours
  2. washThe reaction solution is washed with water
  3. customdried
  4. customevaporated
  5. customto remove the solvent

出典と根拠

ORDレコード
ord-17cfaadae93148f383e4d5451cdfd6d7
出典データセット
uspto-grants-1996_02
特許番号
US05495012

関連ノート

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