Benzaldehyde → 2-Amino-4-hydroxy-4-phenylbutanoic acid

反応式

[CH:1]1[CH:2]=[CH:3][C:4](N)=[C:5]([C:7]([CH2:9][C@H:10]([NH2:14])[C:11]([OH:13])=[O:12])=[O:8])[CH:6]=1.C(=O)C1C=CC=CC=1>>[NH2:14][CH:10]([CH2:9][CH:7]([OH:8])[C:5]1[CH:6]=[CH:1][CH:2]=[CH:3][CH:4]=1)[C:11]([OH:13])=[O:12]

参加物

反応物 2

HCID 240Benzaldehyde

HCID 161166Kynurenine

生成物 1

HCID 119975642-Amino-4-hydroxy-4-phenylbutanoic acid

実験手順

The aldol reaction of L-kynurenine and benzaldehyde catalyzed by kynureninase was found to proceed to give predominantly (80%) the (αS, γR) diastereomer of α-amino-γ-hydroxybenzenebutanoic acid.

出典と根拠

ORDレコード: ord-3e1ab59868c742f2b4cb3193095b5b59
出典データセット: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05495044

反応ノート

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