(3-Amino-4-hydroxyphenyl)acetic acid → 5-Benzoxazoleacetic acid, 2-(4-chlorophenyl)-
反応式
CCO[CH2:4][CH3:5].[ClH:6].[NH2:7][C:8]1[CH:9]=[C:10]([CH2:15][C:16]([OH:18])=[O:17])[CH:11]=[CH:12][C:13]=1[OH:14]>CO>[Cl:6][C:8]1[CH:9]=[CH:10][C:4]([C:5]2[O:14][C:13]3[CH:12]=[CH:11][C:10]([CH2:15][C:16]([OH:18])=[O:17])=[CH:9][C:8]=3[N:7]=2)=[CH:12][CH:13]=1参加物
4
実験手順
A suspension of p-chlorobenzimidoethyl ether hydrochloride (16.5 g.) and 3-amino-4-hydroxyphenylacetic acid (12.53 g.) in methanol (75 ml.) was refluxed for 2 hours. After standing at room temperature overnight the white solid product was removed by filtration. Re-crystallisation from ethanol gave the required acid, m.p. 241° - 242° C.
後処理
- temperaturewas refluxed for 2 hours
- customthe white solid product was removed by filtration
出典と根拠
- ORDレコード
- ord-2038d94571204e3d800a27f571465d69
- 出典データセット
- uspto-grants-1977_05
- 特許番号
- US04021440
反応ノート
読み込み中…