ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

(3-Carboxypropyl)(triphenyl)phosphanium bromide → HCID 86733260、化合物

HRID 2397257
ノート
印刷プレビュー

反応式

HRID 2397257 の反応式
[Br-].C(CCC[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)(O)=O.[Br-].[C:28]([CH2:31][CH:32]([CH3:56])[CH:33]([CH3:55])[CH2:34][CH2:35][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([OH:30])=[O:29].[CH2:57]([O:59][C:60]1([CH2:68][CH2:69]CC=O)[CH:64]=[CH:63][CH:62]([O:65][CH2:66][CH3:67])[O:61]1)[CH3:58].C(OC1(CC=O)C=CC(OCC)O1)C>C(O)C>[CH2:57]([O:59][C:60]1(/[CH:68]=[CH:69]\[CH2:35][CH2:34][CH:33]([CH3:55])[CH:32]([CH3:56])[CH2:31][C:28]([OH:30])=[O:29])[CH:64]=[CH:63][CH:62]([O:65][CH2:66][CH3:67])[O:61]1)[CH3:58]
参加物実験手順出典と根拠反応ノート

参加物

6

反応物 4

HCID 10717451(3-Carboxypropyl)(triphenyl)phosphanium bromideHCID 214374262,5-Dihydro-2,5-diethoxy-2-(2'-oxoethyl)furanHCID 214374312,5-Dihydro-2,5-diethoxy-2-(4'-oxobutyl)furanHCID 86733261HCID 86733261、化合物

生成物 1

HCID 86733260HCID 86733260、化合物

試薬・触媒・溶媒 1

HCID 702
Ethanol
溶媒

実験手順

Adaptation of the above-described procedures to the preparation of the other compounds of this invention essentially involves the lengthening or shortening of, or the introduction of one or two lower alkyl groups into, the side-chains in furans (I) or (XVII) or in phosphonium derivative (III). These adaptations can be accomplished by procedures well-known to the art. For example, isopropyl γ-(2-furyl)-butyrate provides 2,5-dihydro-2,5-di-n-propoxy-2-(3'-carboisopropoxypropyl)furan in n-propanol whereas methyl δ-(2-furyl)valerate provides 2,5-dihydro-2,5-diethoxy-2-(4'-carbomethoxybutyl)furan in ethanol when treated in the manner described for the conversion of (I) to (II). Similarly, ω-(2-furyl)caproic acid and ω-(2-furyl)enanthic acid provide 2,5-dihydro-2,5-diethoxy-2-(5'-carboxyentyl)furan and 2,5-dihydro-2,5-diethoxy-2-(6'-carboxyhexyl)furan when treated in ethanol in the manner described for the conversion of (XVII) to (XVIII). Optionally, the furyl acids may be first esterified prior to oxidative alkoxylation, and all 2,5-dihydro-2,5-dialkoxy-2-(carboalkoxyalkyl)furans may be converted to the corresponding aldehydes in the manner described for the conversion of (II) to (IV). Also, the reaction of 3-carboxypropyltriphenylphosphonium bromide and 5-carboxy-3,4-dimethylamyltriphenylphosphonium bromide with 2,5-dihydro-2,5-diethoxy-2-(4'-oxobutyl)furan and 2,5-dihydro-2,5-diethoxy-2-(2'-oxoethyl)furan, respectively, provides the 2,5-dihydro-2,5-diethoxy-2-(7'-carboxy-4'-cis-heptenyl)furan and 2,5-dihydro-2,5-diethoxy-2-(7'-carboxy-5',6'-dimethyl-2-cis-heptenyl)furan.

出典と根拠

ORDレコード
ord-1181956c3e7144c193012befb4595a69
出典データセット
uspto-grants-1977_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04021452

反応ノート

読み込み中…

このページの内容参加物実験手順出典と根拠反応ノート