Sodium Cyanate → HCID 21423138、化合物

HRID 2397277ノート

反応式

HRID 2397277 の反応式
[O-:1][C:2]#[N:3].[Na+].[CH3:5][O:6][CH:7]1[C:16]2[CH2:15][CH2:14][CH2:13][CH:12]3[CH2:17][CH2:18][O:19][C:10]([C:11]=23)=[CH:9][N:8]1[O:20][CH3:21]>O.C(O)(=O)C>[CH3:5][O:6][CH:7]1[C:16]2[CH2:15][CH:14]([C:2]([NH2:3])=[O:1])[CH2:13][CH:12]3[CH2:17][CH2:18][O:19][C:10]([C:11]=23)=[CH:9][N:8]1[O:20][CH3:21]

参加物

5

反応物 2

HCID 517096Sodium CyanateHCID 20523931HCID 20523931、化合物

生成物 1

HCID 21423138HCID 21423138、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒2 回

実験手順

A solution of sodium cyanate (2.0 g) in water (20 ml) is added dropwise to a solution of 1,2,3a,4,5,6-hexahydro-7,8-dimethoxypyrano[2,3,4-de]isoquinoline (2.0 g), described in Example 56, (2.0 g) in acetic acid (8.0 ml) and water (12.0 ml). The mixture is left at room temperature for 6 hr. and the precipitate is then collected, washed with water, and crystallized from methanol to give the title compound, m.p. 224° - 226° C.

後処理

  1. customand the precipitate is then collected
  2. washwashed with water
  3. customcrystallized from methanol

出典と根拠

ORDレコード
ord-b1f16639d18e451e89d0162bfa42468b
出典データセット
uspto-grants-1977_05
特許番号
US04021451

反応ノート

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