4-Fluorobenzylamine → 2-Pyrrolidinone, 1-((4-fluorophenyl)methyl)-

HRID 2397464

反応式

HRID 2397464 の反応式
[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.[O:10]1[CH:14]=[CH:13][CH2:12][C:11]1=O>C1(C=CC(O)=CC=1)O>[F:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:7]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:10])=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 673264-FluorobenzylamineHCID 1407652(3H)-Furanone

生成物 1

HCID 30454462-Pyrrolidinone, 1-((4-fluorophenyl)methyl)-収率 74.8%

試薬・触媒・溶媒 1

HCID 785Hydroquinone触媒

実験手順

47 g (0.376 mol) of p-fluorobenzylamine, 30.4 g (0.353 mol) of furan-2-one and 0.4 g of hydroquinone are introduced into a 125 ml autoclave. After driving the air out of the apparatus by passing a stream of nitrogen through it, the mixture is heated to 250° for 6 hours. It is then cooled and distilled under reduced pressure. 51 g (yield = 74.8%) of 1-p-fluorobenzyl-pyrrolidin-2-one are collected as a colourless liquid distilling at 103°-105° under a pressure of 0.01 mm of mercury and solidifying slowly. Melting point = 37°-38°.

後処理

  1. temperaturethe mixture is heated to 250° for 6 hours
  2. temperatureIt is then cooled
  3. distillationdistilled under reduced pressure

出典と根拠

ORDレコード
ord-e45f60b7d31d461ba881a4f48816ec96
出典データセット
uspto-grants-1977_05
特許番号
US04021567

関連ノート

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