(Pyridin-4-yl)[3-(trifluoromethyl)phenyl]methanone → ALPHA-[3-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINEMETHANOL

HRID 2397469ノート

反応式

HRID 2397469 の反応式
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([CH:14]=[CH:15][CH:16]=1)[C:6]([C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)=[O:7].[H][H]>CO.Cl.[Pt]=O>[OH:7][CH:6]([CH:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)[C:5]1[CH:14]=[CH:15][CH:16]=[C:3]([C:2]([F:1])([F:17])[F:18])[CH:4]=1

参加物

6

反応物 2

HCID 21438388(Pyridin-4-yl)[3-(trifluoromethyl)phenyl]methanoneHCID 178418361HCID 178418361、化合物2 回

生成物 1

HCID 11392289ALPHA-[3-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINEMETHANOL

試薬・触媒・溶媒 3

HCID 82844Platinum oxide (PtO)触媒HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

A solution of 25.1 g (0.1 mole) of 4-(m-trifluoromethylbenzoyl)pyridine in 150 ml methanol and 10 ml concentrated hydrochloric acid was shaken with one gram of platinum oxide at an initial pressure of fifty psi of hydrogen. The hydrogen uptake was complete in ten hours. The catalyst was filtered off. After removal of the methanol under reduced pressure, the residue was dissolved in water and made basic with sodium hydroxide. Extraction with benzene and concentration of the benzene solution gave crude 4-(alpha-hydroxy-m-trifluoromethylbenzyl)piperidine. Yield 20.2 grams.

後処理

  1. filtrationThe catalyst was filtered off
  2. customAfter removal of the methanol under reduced pressure
  3. dissolutionthe residue was dissolved in water
  4. extractionExtraction with benzene and concentration of the benzene solution

出典と根拠

ORDレコード
ord-3d4de6eb1dd9463faaabceb87b8da30f
出典データセット
uspto-grants-1977_05
特許番号
US04021564

反応ノート

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