6-Chloro-4[(1,1-dimethylethyl)amino]-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester → 4-Amino-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][C:9]([Cl:20])=[C:10]([N+:17]([O-:19])=[O:18])[C:11]=1[NH:12]C(C)(C)C)=[O:5])[CH3:2]>CO>[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:21])=[N:8][C:9]([Cl:20])=[C:10]([N+:17]([O-:19])=[O:18])[C:11]=1[NH2:12])=[O:5])[CH3:2]参加物
3
実験手順
31.6 g. of 6-chloro-4[(1,1-dimethylethyl)amino]-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester (0.1 mol.) are heated with stirring at 250°-260° for 5 minutes. The dark oil is cooled to room temperature and 50 ml. of methyl alcohol are added. 18.2 g. of 4-amino-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester crystallize on cooling (70%), m.p. 89-91° (methanol).
後処理
- customof 4-amino-6-chloro-2-methyl-5-nitropyridine-3-carboxylic acid ethyl ester crystallize