HCID 21436749、化合物 → 1,2,3,4-Tetrahydroisoquinolin-8-amine
反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[CH:12]=[NH+:11][CH:10]=[CH:9]2)([O-])=O.[H][H]>[Pt]=O.CO>[NH2:1][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[CH2:12][NH:11][CH2:10][CH2:9]2参加物
5
実験手順
The 2-lower alkyl-5,6,7, or 8-nitroisoquinolinium salt can be catalytically hydrogenated directly to a 2-lower alkyl-5,6,7 or 8-amino-1,2,3,4-tetrahydroisquinoline. The hydrogenation can be readily effected by use of a platinum oxide catalyst in methanol and a hydrogen pressure of about 25 to 100 psi. The hydrogenation proceeds at room temperature. After filtering to remove the catalyst, the filtrate can be worked up to obtain the 2-lower alkyl-5,6,7 or 8-amino-1,2,3,4-tetrahydroisoquinoline.
後処理
- customproceeds at room temperature
- filtrationAfter filtering
- customto remove the catalyst
出典と根拠
- ORDレコード
- ord-778cb547fcb14cceaf5882ab74ffd555
- 出典データセット
- uspto-grants-1977_05
- 特許番号
- US04022900
反応ノート
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