HCID 21436737、化合物 → HCID 21436740、化合物

HRID 2397925ノート

反応式

HRID 2397925 の反応式
[Br-:1].[N+:2]([C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][N+:9]([CH2:15][CH2:16][CH3:17])=[CH:10]2)([O-])=O>CO.[Pt]=O>[BrH:1].[NH2:2][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH2:7][CH2:8][N:9]([CH2:15][CH2:16][CH3:17])[CH2:10]2

参加物

4

反応物 1

HCID 21436737HCID 21436737、化合物

生成物 1

HCID 21436740HCID 21436740、化合物収率 100.2%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 887Methanol溶媒

実験手順

5-Nitro-2-n-propylisoquinolinium bromide (8.2 g) was dissolved in methanol (150 ml) and the solution hydrogenated over platinum oxide (0.6 g) at 45 psi. When the hydrogenation was complete, the catalyst was removed by filtration and the solvent removed in vacuo to leave a light orange solid residue of 5-amino-2-n-propyl-1,2,3,4-tetrahydroisoquinoline hydrobromide (7.5 g). This residue was recrystallized from ethanol and the product obtained as pale orange crystals, m.p. 238°-239.5° C.

後処理

  1. customthe catalyst was removed by filtration
  2. customthe solvent removed in vacuo

出典と根拠

ORDレコード
ord-cceff6d68eeb4094a9558e8d4d59a204
出典データセット
uspto-grants-1977_05
特許番号
US04022900

反応ノート

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