Dimethylamine → 4-(Dimethylamino)butane-2-sulfonic acid

HRID 239794

反応式

HRID 239794 の反応式
[CH3:1][CH:2]1[S:6](=[O:8])(=[O:7])[O:5][CH2:4][CH2:3]1.[CH3:9][NH:10][CH3:11]>>[CH3:9][N:10]([CH3:11])[CH2:4][CH2:3][CH:2]([S:6]([OH:5])(=[O:8])=[O:7])[CH3:1]

参加物

3

反応物 2

HCID 674DimethylamineHCID 707161,2-Oxathiolane, 3-methyl-, 2,2-dioxide

生成物 1

HCID 587946244-(Dimethylamino)butane-2-sulfonic acid

反応条件

温度
0 °C

実験手順

2,4-butanesultone (1.27 g, 8.9 mmol) was added to an ice-chilled solution of dimethylamine (40% w/w in water). The solution was stirred at 0° C. for 4 hours. The solvent was evaporated in vacuo until complete dryness. The solid was washed with acetone (50 mL), collected by filtration and dried in vacuo. 1H NMR (D2O, 500 MHz) δ ppm 3.18 (t, 2H, J=8.1 Hz), 2.85 (m, 1H), 2.76 (s, 6H), 2.09 (m, 1H), 1.81 (m, 1H), 1.17 (d, 3H, J=7.3 Hz). 13C (D2O, 125 MHz) δ ppm 55.65, 53.05, 42.88, 26.72, 14.81. ES-MS182a (M+1).

後処理

  1. customThe solvent was evaporated in vacuo until complete dryness
  2. washThe solid was washed with acetone (50 mL)
  3. filtrationcollected by filtration
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-114e0e33c64c4fbda180f55083797151
出典データセット
uspto-grants-2014_02
特許番号
US08642801B2

関連ノート

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