2-Iodobenzoyl chloride → 2-Iodo-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)benzene-1-carboximidic acid

反応式

[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2.[I:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16](Cl)=[O:17]>>[I:13][C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16]([NH:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][N:6]([CH3:12])[CH2:7]2)=[O:17]

参加物

反応物 2

HCID 691122-Iodobenzoyl chloride

HCID 141712692-Methyl-1,2,3,4-tetrahydroisoquinolin-5-amine

生成物 1

HCID 2166002-Iodo-N-(2-methyl-1,2,3,4-tetrahydroisoquinolin-5-yl)benzene-1-carboximidic acid

実験手順

5-Amino-2-methyl-1,2,3,4-tetrahydroisoquinoline was reacted with 2-iodobenzoyl chloride according to the procedure of Example 19 to yield 5-(2-iodobenzamido)-2-methyl-1,2,3,4-tetrahydroisoquinoline; m.p. 215°-216.5° C. after purification from methanol.

出典と根拠

ORDレコード: ord-cbfa98e359de46aaa9e593f3a0295317
出典データセット: uspto-grants-1977_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04022900

反応ノート

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