Sodium Bicarbonate → 1alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

HRID 2397973ノート

反応式

HRID 2397973 の反応式
[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][O:22]C(=O)CC)[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3].C(=O)(O)[O-].[Na+]>CO>[C:1]([O:5][C@H:6]1[CH2:11][CH2:10][C@H:9]2[C@H:12]3[C@H:27]([CH2:28][CH2:29][C@:7]12[CH3:8])[C@:20]1([CH2:21][OH:22])[C:15](=[CH:16][CH2:17][CH2:18][C@@H:19]1[CH3:30])[CH2:14][CH2:13]3)(=[O:4])[CH2:2][CH3:3]

参加物

4

反応物 2

HCID 516892Sodium BicarbonateHCID 705838891alpha-Methyl-4-androstene-17beta,19-diol dipropionate

生成物 1

HCID 705847651alpha-Methyl-4-androstene-17beta,19-diol 17-propionate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1α-Methyl-4-androstene-17β,19-diol dipropionate is dissolved in a 10% aqueous methanol solution and one equivalent of sodium bicarbonate is added. The solution is stirred and heated at its reflux temperature for one hour and poured onto ice water with vigorous stirring. The precipitate is removed by filtration, air dried and crystallized from hexane to yield 1α-methyl-4-androstene-17β,19-diol 17-propionate.

後処理

  1. additionis added
  2. temperatureheated at its
  3. temperaturereflux temperature for one hour
  4. additionpoured onto ice water with vigorous stirring
  5. customThe precipitate is removed by filtration, air
  6. customdried
  7. customcrystallized from hexane

出典と根拠

ORDレコード
ord-058026ca909142dd97a15bf7314057cc
出典データセット
uspto-grants-1977_05
特許番号
US04022769

反応ノート

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