4-Methoxybenzenesulfonyl chloride → N-(2-benzoyl-4-fluoro-phenyl)-4-methoxy-benzenesulfonamide

HRID 239824ノート

反応式

HRID 239824 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:10].[CH3:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1>>[C:9]([C:3]1[CH:4]=[C:5]([F:8])[CH:6]=[CH:7][C:2]=1[NH:1][S:25]([C:22]1[CH:21]=[CH:20][C:19]([O:18][CH3:17])=[CH:24][CH:23]=1)(=[O:27])=[O:26])(=[O:10])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

3

反応物 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 778082(2-Amino-5-fluorophenyl)(phenyl)methanone

生成物 1

HCID 10430172N-(2-benzoyl-4-fluoro-phenyl)-4-methoxy-benzenesulfonamide

実験手順

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously described using 115 mg of (2-amino-5-fluoro-phenyl)-phenyl-methanone and 101 mg of 4-methoxy-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 3.64 (s, 3H), 6.62 (d, 2H, J=9.2 Hz), 7.02 (m, 1H), 7.25 (m, 1H), 7.31 (m, 2H), 7.37 (m, 2H), 7.48 (m, 2H), 7.56 (m, 1H), 7.79 (q, 1H, J=9.2 Hz, 4.8 Hz), 9.34 (s, 1H). MS: m/z 386.0 (M++1).

出典と根拠

ORDレコード
ord-8cc914b8e69242a198b6b19426f13095
出典データセット
uspto-grants-2014_02
特許番号
US08642808B2

反応ノート

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