Acetone → 1-(4-chlorophenyl)-2-phenoxyethanone

HRID 2398473ノート

反応式

HRID 2398473 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].[C:12]1([OH:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+].CC(C)=O>O>[O:18]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 180AcetoneHCID 996PhenolHCID 11430Potassium CarbonateHCID 68303p-Chlorophenacyl bromide

生成物 1

HCID 14715261-(4-chlorophenyl)-2-phenoxyethanone

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 23.3 g. (0.1 mol.) of α-bromo-p-chloroacetophenone, 10.0 g. (0.1 mol.) of phenol and 14.5 g. (0.1 mol.) of potassium carbonate in 65 ml. of dry acetone is refluxed for 12 hours. The reaction mixture is cooled, poured into 500 ml. of water and the precipitate formed is collected by filtration and recrystallized from ethanol to give α-phenoxy-p-chloroacetophenone.

後処理

  1. additionA mixture of 23.3 g
  2. temperatureThe reaction mixture is cooled
  3. additionpoured into 500 ml
  4. filtrationis collected by filtration
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-7e1122842d8347b788d818eed2b75589
出典データセット
uspto-grants-1977_05
特許番号
US04024273

反応ノート

読み込み中…