Ethylamine → Ethyl 3-(ethylamino)-3-oxopropanoate
反応式
[C:1]([CH2:6][C:7](Cl)=[O:8])([O:3][CH2:4][CH3:5])=[O:2].[CH2:10]([NH2:12])[CH3:11]>C1C=CC=CC=1>[CH2:10]([NH:12][C:7](=[O:8])[CH2:6][C:1]([O:3][CH2:4][CH3:5])=[O:2])[CH3:11]参加物
4
実験手順
To 15.0 g. (0.1 mole) of carboethoxyacetyl chloride in 150 ml. of benzene is added, with cooling, 9.9 g. (0.22 mole) of ethylamine in 50 ml. of the same solvent. The reaction mixture is allowed to stir at room temperature overnight, followed by filtration. The filtrate is washed with water, dried over sodium sulfate and concentrated to dryness. The residual product is washed several times with diisopropyl ether and dried in vacuo. The crude product is employed in the next reaction without further purification.
後処理
- temperaturewith cooling
- filtrationfollowed by filtration
- washThe filtrate is washed with water
- dry with materialdried over sodium sulfate
- concentrationconcentrated to dryness
- washThe residual product is washed several times with diisopropyl ether
- customdried in vacuo
- customThe crude product is employed in the next reaction without further purification
出典と根拠
- ORDレコード
- ord-4828fce972cb42fc92a4c50465ed5eea
- 出典データセット
- uspto-grants-1977_05
- 特許番号
- US04025504
反応ノート
読み込み中…