Phosphorus pentachloride → HCID 178479351、化合物

HRID 2398609ノート

反応式

HRID 2398609 の反応式
[ClH:1].[C:2]([NH:10][CH2:11][C:12]([OH:14])=O)(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:16]>C(Cl)Cl>[ClH:16].[C:2]([NH:10][CH2:11][C:12]([Cl:1])=[O:14])(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 24819Phosphorus pentachlorideHCID 178479352HCID 178479352、化合物

生成物 1

HCID 178479351HCID 178479351、化合物収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To benzimidoylaminoacetic acid hydrochloride (2.2 g., 10 m moles) in 40 ml. of dry methylene chloride is added 2.5 g. (12 m moles) of phosphorous pentachloride, and the reaction mixture allowed to stir overnight at room temperature. The product is filtered, washed successively with methylene chloride (50 ml.), chloroform 2× 75 ml.) and hexane (50 ml.) and dried in vacuo, 2.5 g. (99% yield).

後処理

  1. filtrationThe product is filtered
  2. washwashed successively with methylene chloride (50 ml.), chloroform 2× 75 ml
  3. dry with material) and hexane (50 ml.) and dried in vacuo, 2.5 g

出典と根拠

ORDレコード
ord-d6cf1e7b675947c7acb482853552c6f8
出典データセット
uspto-grants-1977_05
特許番号
US04025504

反応ノート

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