Phosphorus pentachloride → HCID 178479351、化合物

HRID 2398626ノート

反応式

HRID 2398626 の反応式
[ClH:1].[C:2]([NH:10][CH2:11][C:12]([OH:14])=O)(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:16]>C(Cl)Cl>[ClH:16].[C:2]([NH:10][CH2:11][C:12]([Cl:1])=[O:14])(=[NH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 24819Phosphorus pentachlorideHCID 178479352HCID 178479352、化合物

生成物 1

HCID 178479351HCID 178479351、化合物収率 99%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To benzimidoylaminoacetic acid hydrochloride (2.2 g., 10 mmoles) in 40 ml. of dry methylene chloride is added 2.5 g. (12 mmoles) of phosphorous pentachloride, and the reaction mixture allowed to stir overnight at room temperature. The product is filtered, washed successively with methylene chloride (50 ml. ), chloroform 2× 75 ml.) and hexane (50 ml.) and dried in vacuo, 2.5 g. (99% yield).

後処理

  1. filtrationThe product is filtered
  2. washwashed successively with methylene chloride (50 ml. ), chloroform 2× 75 ml
  3. dry with material) and hexane (50 ml.) and dried in vacuo, 2.5 g

出典と根拠

ORDレコード
ord-8472ed6ac61a4e67b131e5ed0c83f3cf
出典データセット
uspto-grants-1977_05
特許番号
US04025506

反応ノート

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