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Cyclohexanol → 5-Cyclohexyloxy-2-carbomethoxyaminobenzimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexanol | HCID 7966 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 5-Chloro-2-nitroaniline | HCID 74218 | — |
| 反応物 | Methyl N-cyanocarbamate | HCID 89023 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Cyclohexyloxy-2-carbomethoxyaminobenzimidazole | HCID 20284434 | — |
反応手順
A mixture of cyclohexanol (0.03 mol) in 75 ml. of dry dimethylformamide under nitrogen is agitated while 55% sodium hydride (0.03 mol) in oil is added portionwise. When evolution of hydrogen ceases 2-nitro-5-chloroaniline (0.025 mol) is added with stirring. The mixture is warmed at 75°-80° C. for 1 hour then poured onto 6 volumes of ice slurry. The separated product recrystallized from water to give red crystals of the nitroaminobiphenylether. After hydrogenation and reaction with carbomethoxycyanamide as described above the product, 5-cyclohexyloxy-2-carbomethoxyaminobenzimidazole is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04025638 |
| 出典データセット | uspto-grants-1977_05 |
| ORD ID | ord-1c5f0135e69a40848c0e08e99d8c8114 |
| 出典メモ | uspto-grants-1977_05 |