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2-Fluoro-5-methylphenyl isocyanate → N-(4-bromo-2-ethylphenyl)-N'-(2-fluoro-5-methylphenyl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Fluoro-5-methylphenyl isocyanate | HCID 2733377 | — |
| 反応物 | 4-Bromo-2-ethylaniline | HCID 2801283 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(4-bromo-2-ethylphenyl)-N'-(2-fluoro-5-methylphenyl)urea | HCID 66680634 | 64.7% |
反応手順
A solution of 4-bromo-2-ethylaniline (200 mg) in dichloromethane (10 mL) was treated with 1-fluoro-2-isocyanato-4-methylbenzene (151 mg), stirred at room temperature overnight, diluted with hexanes, and filtered. The filter cake provided 227 mg of the desired product. MS (ESI(+)) m/e 351,353 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08642776B2 |
| 出典データセット | uspto-grants-2014_02 |
| ORD ID | ord-2b6b93845cc1458e9aa075848bbde5c7 |
| 出典メモ | uspto-grants-2014_02 |