Dicyclohexylcarbodiimide → 2-Benzyl-5,5-dimethyl-10-[4-(2-methylpiperidino)butyryloxy]-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine hydrochloride

HRID 2398871

反応式

HRID 2398871 の反応式
[CH2:1]([N:8]1[CH2:13][C:12]2[C:14]3[C:23]([OH:24])=[CH:22][C:21]([C:25]([C:30]4[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=4[CH3:37])([CH3:29])[CH2:26][CH2:27][CH3:28])=[CH:20][C:15]=3[O:16][C:17]([CH3:19])([CH3:18])[C:11]=2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:39][CH:40]1[CH2:45][CH2:44][CH2:43][CH2:42][N:41]1[CH2:46][CH2:47][CH2:48][C:49](O)=[O:50].C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:36].[CH2:1]([N:8]1[CH2:13][C:12]2[C:14]3[C:23]([O:24][C:49](=[O:50])[CH2:48][CH2:47][CH2:46][N:41]4[CH2:42][CH2:43][CH2:44][CH2:45][CH:40]4[CH3:39])=[CH:22][C:21]([C:25]([C:30]4[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=4[CH3:37])([CH3:29])[CH2:26][CH2:27][CH3:28])=[CH:20][C:15]=3[O:16][C:17]([CH3:18])([CH3:19])[C:11]=2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 541700422-Benzyl-5,5-dimethyl-10-hydroxy-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridineHCID 705657274-(2-Methylpiperidin-1-yl)butanoic acid hydrochloride

生成物 1

HCID 706236672-Benzyl-5,5-dimethyl-10-[4-(2-methylpiperidino)butyryloxy]-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine hydrochloride

実験手順

2-Benzyl-5,5-dimethyl-10-hydroxy-8-(2-methyl-5-chlorophenyl-1-methylbutyl)-1,2,3,4-tetrahydro-5H[1]benzopyrano[3,4-d]pyridine, γ-(2-methylpiperidino)-butyric acid hydrochloride and dicyclohexylcarbodiimide in equimolar amounts are reacted as in Example 7 to give the desired product.

出典と根拠

ORDレコード
ord-d1171128ef384a2981635228d2ed0a18
出典データセット
uspto-grants-1977_05
特許番号
US04025630

関連ノート

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