Ammonia → 3-(3-Nitro-4-aminobenzoyl)pyridine

HRID 2399035ノート

反応式

HRID 2399035 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1Cl)[C:7]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:8])([O-:3])=[O:2].[NH3:19]>C(O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[NH2:19])[C:7]([C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:8])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 222AmmoniaHCID 214326003-(3-Nitro-4-chlorobenzoyl)pyridine

生成物 1

HCID 214325873-(3-Nitro-4-aminobenzoyl)pyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A suspension of 63 g. (0.24 mol) of 3-(3-nitro-4-chlorobenzoyl)pyridine in 3 liters of a saturated solution of ammonia in ethanol was autoclaved at 100° C. for 24 hours. The mixture was concentrated in vacuo and the resulting residue dissolved in 1.5 liters of warm 5N HCl. The solution was cooled to room temperature and neutralized with concentrated ammonium hydroxide. The resulting product was collected as yellow-orange prisms, mp. 229° -230° C. (dimethylformamide-2-propanol).

後処理

  1. additionA suspension of 63 g
  2. concentrationThe mixture was concentrated in vacuo
  3. dissolutionthe resulting residue dissolved in 1.5 liters of warm 5N HCl
  4. customThe resulting product was collected as yellow-orange prisms, mp. 229° -230° C. (dimethylformamide-2-propanol)

出典と根拠

ORDレコード
ord-cec53df07eca460888cad9af9ad2a29e
出典データセット
uspto-grants-1977_05
特許番号
US04026936

反応ノート

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