Potassium Carbonate → N-[2-(2-Pyridylmethylthio)ethyl]thiourea

HRID 2399125ノート

反応式

HRID 2399125 の反応式
C([NH:9][C:10]([NH:12][CH2:13][CH2:14][S:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1)=[S:11])(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>O>[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][S:15][CH2:14][CH2:13][NH:12][C:10]([NH2:9])=[S:11]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 21432770N-benzoyl-N'-[2-(2-pyridylmethylthio)ethyl]thiourea

生成物 1

HCID 21432760N-[2-(2-Pyridylmethylthio)ethyl]thiourea

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The benzoyl thiourea is added to a solution of potassium carbonate (1.4 g.) in water (80 ml.) at 60°. The solution is maintained at this temperature for one hour, concentrated to low bulk and acidified with hydrochloric acid. Benzoic acid is removed by filtration and the filtrate is basified with potassium carbonate and concentrated under reduced pressure. Following extraction with isopropyl alcohol and concentration, the product is N-[2-(2-pyridylmethylthio)ethyl]thiourea.

後処理

  1. temperatureThe solution is maintained at this temperature for one hour
  2. concentrationconcentrated to low bulk
  3. customBenzoic acid is removed by filtration
  4. concentrationconcentrated under reduced pressure
  5. extractionextraction
  6. concentrationwith isopropyl alcohol and concentration

出典と根拠

ORDレコード
ord-fa2c0217bf0a41358db4f7b440311365
出典データセット
uspto-grants-1977_05
特許番号
US04027026

反応ノート

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