4-(N-Propionylaniline)piperidine → N-(2,6-dimethylphenoxyethyl)-4-(N'-phenyl-N'-propylamino)-piperidine

HRID 2399171

反応式

HRID 2399171 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6]Br.[C:13]1([N:19]([CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[C:20](=O)[CH2:21][CH3:22])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH3:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[C:3]=1[O:4][CH2:5][CH2:6][N:27]1[CH2:28][CH2:29][CH:24]([N:19]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:20][CH2:21][CH3:22])[CH2:25][CH2:26]1

参加物

3

反応物 2

HCID 2593814-(N-Propionylaniline)piperidineHCID 24522082-(2-Bromoethoxy)-1,3-dimethylbenzene

生成物 1

HCID 54259289N-(2,6-dimethylphenoxyethyl)-4-(N'-phenyl-N'-propylamino)-piperidine収率 79.7%

実験手順

Using the procedure described in Example I and starting from 12.7 g (2,6-dimethylphenoxyethyl) bromide and 12.8 g 4-(N'-phenyl-N'-propionylamino)-piperidine, 16.1 g of the title product are obtained melting at 82° after recrystallization from hexane. Mixing the compound with 4-(N'-phenyl-N'-propionylamino)-piperidine depresses the melting point.

出典と根拠

ORDレコード
ord-37cb28822f0a47079faff14e341d37ae
出典データセット
uspto-grants-1977_05
特許番号
US04027028

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