化工社化工社 化学情報印刷レポート · 研究参考用
Benzene, (2-chloroethoxy)- → Phenoxyethyl-norfentanyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzene, (2-chloroethoxy)- | HCID 12156 | — |
| 反応物 | 4-(N-Propionylaniline)piperidine | HCID 259381 | — |
| 生成物 | Phenoxyethyl-norfentanyl | HCID 54005394 | 98.6% |
反応手順
By condensing 14.7 g 4-(N'-phenyl-N'-propionylamino)-piperidine and 19.9 g phenoxyethyl chloride, they are obtained after 24 hours reflux 22 g of the title product which after recrystallization from hot cyclohexane gives a first crop weighing 13.5 g. The pure compound melts at 100°-102°. It is soluble in hydrochloric acid. The solution after distillation leads to the recovery of the hydrochloride. The hydrochloride is soluble in water.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04027028 |
| 出典データセット | uspto-grants-1977_05 |
| ORD ID | ord-06dc97e744cf48a0a7842a8396006747 |
| 出典メモ | uspto-grants-1977_05 |