Sodium Cyanide → HCID 18973689、化合物

HRID 2399414ノート

反応式

HRID 2399414 の反応式
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:9]Cl)[CH2:3][CH2:2]1.[C-:18]#[N:19].[Na+]>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]([CH2:9][C:18]#[N:19])[CH:11]=[CH:12][C:13]=2[O:14][CH:15]([F:17])[F:16])[CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 8929Sodium CyanideHCID 18973686HCID 18973686、化合物

生成物 1

HCID 18973689HCID 18973689、化合物収率 95.7%

実験手順

To 3-cyclopropylmethoxy-4-difluoromethoxybenzyl chloride (26 g) in dimethylflormamide (150 mL) under an argon atmosphere was added sodium cyanide (9.7 g, 198 mmol). The resulting mixture was stirred at room temperature and heated gently for 2 h, then cooled and concentrated. The mixture was partitioned between basic brine and ether and extracted twice. The organic extract was washed with brine and was dried (sodium sulfate). The solvent was removed in vacuo to provide an orange-brown oil (24 g), which was used without purification.

後処理

  1. temperatureheated gently for 2 h
  2. temperaturecooled
  3. concentrationconcentrated
  4. customThe mixture was partitioned between basic brine and ether
  5. extractionextracted twice
  6. extractionThe organic extract
  7. washwas washed with brine
  8. dry with materialwas dried (sodium sulfate)
  9. customThe solvent was removed in vacuo

出典と根拠

ORDレコード
ord-a1dbcaa1f8484773b9b4c71d9207d02b
出典データセット
uspto-grants-1995_09
特許番号
US05449686

反応ノート

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