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Phenol → Methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenol | HCID 996 | — |
| 反応物 | 3-Chloro-4-hydroxy-5-methoxybenzaldehyde | HCID 29622 | — |
| 反応物 | Methyl 2-(2-bromophenyl)acetate | HCID 8063364 | — |
| 反応物 | Acetone potassium carbonate | HCID 86600397 | — |
| 生成物 | Methyl 2-(2-chloro-4-hydroxymethyl-6-methoxyphenoxy)-2-phenylacetate | HCID 19385663 | 64.6% |
反応手順
Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 0.50 g (2.62 mmol) of 3-chloro-4-hydroxy-5-methoxybenzaldehyde was alkylated with 0.668 g (2.92 mmol) of methyl 2-bromophenylacetate to afford 0.570 g (64%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05449682 |
| 出典データセット | uspto-grants-1995_09 |
| ORD ID | ord-6db11a8b3b2b471294602241b46af3cf |
| 出典メモ | uspto-grants-1995_09 |