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Triethylamine → 4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-methyl-2-phenyl-N-prop-2-ynyl-butyramide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | N-methylpropyn-2-ylamine | HCID 96160 | — |
| 反応物 | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| 反応物 | 4-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenylbutanoic acid | HCID 9863428 | — |
| 反応物 | N,N-bis(2-oxo-3oxazolidinyl)phosphoramidic chloride | HCID 19975454 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-methyl-2-phenyl-N-prop-2-ynyl-butyramide | HCID 9931130 | 93.7% |
反応手順
The title compound was prepared from 4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylbutanoic acid (1.77 g, 5 mmole), triethylamine (1.518 g, 15 mmole), N,N-bis(2-oxo-3-oxazolidinyl)phosphoramidic chloride (1.527 g, 6 mmole), N-methylpropargylamine (0.415 g, 6 mmole) and methylene chloride (80 mL) in the manner described in Example 1, to yield 1.9 g of the title compound as the dihydrochloride, m.p. 197°-8° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05451584 |
| 出典データセット | uspto-grants-1995_09 |
| ORD ID | ord-0c3e5acfb8c84853803d0dae23d61440 |
| 出典メモ | uspto-grants-1995_09 |